![]() From this scientific perspective, EBM is contrasted with the former paradigm of clinical medicine, in which medical knowledge was based on pathophysiological reasoning and clinical experience. To base assumptions upon evidence is a core feature of science and by its explicit appeal to evidence, EBM claims to be founded on the scientific method, where new knowledge results from experimental evidence, subjected to specific principles of reasoning. Evidence may be defined as anything supporting the truth of something else. ![]() In a narrower sense, EBM refers to evidence-based medical practice, with cornerstones including that clinical decisions should be based on the best available scientific evidence and that the clinical problem (and not habits or protocols) should determine the type of evidence to be sought. ![]() Introduction Evidence-based medicine (EBM) is listed as one of the 15 greatest medical milestones since 1840, along with the discovery of DNA structure, antibiotics, vaccines and viruses. Journal of Evaluation in Clinical Practice ISSN 1365-2753Įvidence-based medical knowledge: the neglected role of expert opinion Jeannette Hofmeijer MD PhD1,2 1Īssistant Professor, Clinical Neurophysiology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands 2Neurologist, Department of Neurology, Rijnstate Hospital, Arnhem, The Netherlands
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